Topiramate modulates hippocampus NMDA receptors via brain Ca2+ homeostasis in pentylentetrazol-induced epilepsy of rats


Yilmaz M., NAZIROĞLU M. , KUTLUHAN S. , Yilmaz N., YÜREKLİ V. A. , Vural H.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, vol.31, no.2, pp.173-179, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.3109/10799893.2011.555914
  • Title of Journal : JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
  • Page Numbers: pp.173-179

Abstract

Background: Increase in neuronal Ca2+, activation of hippocampus N-methyl-D-aspartate receptor (NMDAR) and defects in enzymes such as brain cortex microsomal membrane Ca2+-ATPase (MMCA) are thought to play a role in epilepsy. Topiramate (TOP) is a novel drug with broad antiepileptic effect, and its effect on brain cortex MMCA is not known. We investigated effects of TOP on pentylentetrazol (PTZ)-induced MMCA activity and NMDAR subunits in rat brain.