Pyrazoline and Hydrazone Derivatives as Potent Membrane Stabilizer and Antioxidant Compounds

EVRANOS AKSÖZ B. , YILMAZ SARIALTIN S., ÇOBAN T.

PHARMACEUTICAL CHEMISTRY JOURNAL, pp.220-225, 2022 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1007/s11094-022-02624-z
  • Title of Journal : PHARMACEUTICAL CHEMISTRY JOURNAL
  • Page Numbers: pp.220-225
  • Keywords: membrane stabilizing activity, antioxidant, pyrazoline, hydrazone, OXIDATIVE STRESS

Abstract

Membrane-stabilizing and antioxidant activities of twenty six pyrazoline and hydrazone derivatives were investigated. Antioxidant activity of these compounds was examined by using in vitro 2,2-azino-bis(3-ethyl-benzothiazoline-6-sulphonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assays. Butylated hydroxytoluene (BHT) was used as DPPH center dot free radical scavenger standard, and trolox was used as ABTS(center dot+) free radical scavenger standard. Some compounds (D13, D16 and D22) showed good antioxidant activity. All compounds were found to exhibit better membrane stabilizing activity than the reference acetylsalicylic acid.