Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects

Fujita, Hiroyuki; Chalubinski, Maciej; Rhyner, Claudio; Indermitte, Philippe; Meyer, Norbert; Ferstl, Ruth; Treis, Angela; Gomez, Enrique; AKKAYA, Ahmet; O'Mahony, Liam; Akdis, Muebeccel; Akdis, Cezmi

doi:10.1016/j.jaci.2011.03.039

Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects

Fujita H., Chalubinski M., Rhyner C., Indermitte P., Meyer N., Ferstl R., ...Daha Fazla

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, cilt.127, sa.6, ss.1612-1629, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 127 Sayı: 6
Basım Tarihi: 2011
Doi Numarası: 10.1016/j.jaci.2011.03.039
Dergi Adı: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1612-1629
Süleyman Demirel Üniversitesi Adresli: Evet

Özet

Background: Increased airway smooth muscle (ASM) mass is an essential component of airway remodeling and asthma development, and there is no medication specifically against it. Tight junction (TJ) proteins, which are expressed in endothelial and epithelial cells and affect tissue integrity, might exist in other types of cells and display additional functions in the asthmatic lung.