Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects


Fujita H., Chalubinski M., Rhyner C., Indermitte P., Meyer N., Ferstl R., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.127, no.6, pp.1612-1629, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 127 Issue: 6
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jaci.2011.03.039
  • Title of Journal : JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Page Numbers: pp.1612-1629

Abstract

Background: Increased airway smooth muscle (ASM) mass is an essential component of airway remodeling and asthma development, and there is no medication specifically against it. Tight junction (TJ) proteins, which are expressed in endothelial and epithelial cells and affect tissue integrity, might exist in other types of cells and display additional functions in the asthmatic lung.