Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects


Fujita H., Chalubinski M., Rhyner C., Indermitte P., Meyer N., Ferstl R., ...Daha Fazla

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, cilt.127, ss.1612-1629, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 127 Konu: 6
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.jaci.2011.03.039
  • Dergi Adı: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Sayfa Sayıları: ss.1612-1629

Özet

Background: Increased airway smooth muscle (ASM) mass is an essential component of airway remodeling and asthma development, and there is no medication specifically against it. Tight junction (TJ) proteins, which are expressed in endothelial and epithelial cells and affect tissue integrity, might exist in other types of cells and display additional functions in the asthmatic lung.