Correlation of F-18-FDG/PET SUVmax, SUVmean, MTV, and TLG with HIF-1 alpha in Patients with Colorectal Cancer
MOLECULAR IMAGING AND RADIONUCLIDE THERAPY, cilt.30, sa.2, ss.93-100, 2021 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 2
- Basım Tarihi: 2021
- Doi Numarası: 10.4274/mirt.galenos.2021.04934
- Dergi Adı: MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.93-100
- Anahtar Kelimeler: Hypoxia-inducible factor-1 alpha, colorectal cancer, F-18-FDG/PET/CT, MTV, TLG, HYPOXIA-INDUCIBLE FACTOR-1-ALPHA, TUMOR ANGIOGENESIS, FACTOR 1-ALPHA, UNFAVORABLE PROGNOSIS, FACTOR-I, EXPRESSION, OVEREXPRESSION, QUANTIFICATION, METASTASIS, CARCINOMA
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Objectives: Post-hypoxia hypoxia-inducible factor (HIF)-1 alpha activation plays a vital role in colorectal cancer (CRC) angiogenesis. Although glucose metabolism is induced in some cancer types via HIF-1 alpha, the prognostic significance of HIF-1 alpha in CRC and its correlation with 18-fluorinefluorodeoxyglucose (F-18-FDG) uptake in positron emission tomography (PET) remain controversial. This study aims to investigate the association between F-18-FDG/PET parameters and HIF-1 alpha expression in CRC.