Correlation of F-18-FDG/PET SUVmax, SUVmean, MTV, and TLG with HIF-1 alpha in Patients with Colorectal Cancer

KAYMAK Z. A. , KARAHAN N., ERDOĞAN M., ERDEMOĞLU E., ZİHNİ İ., ŞENGÜL S. S.

MOLECULAR IMAGING AND RADIONUCLIDE THERAPY, vol.30, no.2, pp.93-100, 2021 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.4274/mirt.galenos.2021.04934
  • Journal Name: MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.93-100
  • Keywords: Hypoxia-inducible factor-1 alpha, colorectal cancer, F-18-FDG/PET/CT, MTV, TLG, HYPOXIA-INDUCIBLE FACTOR-1-ALPHA, TUMOR ANGIOGENESIS, FACTOR 1-ALPHA, UNFAVORABLE PROGNOSIS, FACTOR-I, EXPRESSION, OVEREXPRESSION, QUANTIFICATION, METASTASIS, CARCINOMA
  • Süleyman Demirel University Affiliated: Yes

Abstract

Objectives: Post-hypoxia hypoxia-inducible factor (HIF)-1 alpha activation plays a vital role in colorectal cancer (CRC) angiogenesis. Although glucose metabolism is induced in some cancer types via HIF-1 alpha, the prognostic significance of HIF-1 alpha in CRC and its correlation with 18-fluorinefluorodeoxyglucose (F-18-FDG) uptake in positron emission tomography (PET) remain controversial. This study aims to investigate the association between F-18-FDG/PET parameters and HIF-1 alpha expression in CRC.