Endostatin in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events and survival


Kanbay M., Afsar B. , Siriopol D., Unal H. U. , Karaman M., Saglamf M., ...More

EUROPEAN JOURNAL OF INTERNAL MEDICINE, vol.33, pp.81-87, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33
  • Publication Date: 2016
  • Doi Number: 10.1016/j.ejim.2016.06.033
  • Title of Journal : EUROPEAN JOURNAL OF INTERNAL MEDICINE
  • Page Numbers: pp.81-87

Abstract

Background and aims: Endostatin, generated from collagen XVIII, and endorepellin, possess dual activity as modifiers of both angiogenesis and endothelial cell autophagy. Plasma endostatin levels are elevated in a large number of diseases, and may reflect endothelial cell dysfunction. Few data on endostatins are available for patients with chronic kidney disease (CKD). We tested whether serum endostatin values are predictive for all-cause mortality and cardiovascular events (CVEs) in a CKD population.