Protective effects of vitamins C and E against endometrial damage and oxidative stress in fluoride intoxication

Guney, Mehmet; Oral, Hilmi; Demirin, Hilmi; Karahan, Nermin; Mungan, Tamer; Delibas, Namik

doi:10.1111/j.1440-1681.2007.04596.x

Protective effects of vitamins C and E against endometrial damage and oxidative stress in fluoride intoxication

Guney M., Oral B., Demirin H., Karahan N., Mungan T., Delibas N.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.34, ss.467-474, 2007 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 34
Basım Tarihi: 2007
Doi Numarası: 10.1111/j.1440-1681.2007.04596.x
Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.467-474
Süleyman Demirel Üniversitesi Adresli: Evet

Özet

1. Fluoride (F) is an essential trace element that has protective effects against bone mineral loss. However, it becomes toxic at higher doses and induces some adverse effects on a number of physiological functions, including reproduction. The aims of this study were to examine F-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of vitamins C and E against possible F-induced endometrial impairment in rats.