Protective effects of vitamins C and E against endometrial damage and oxidative stress in fluoride intoxication

Guney, Mehmet; Oral, Hilmi; Demirin, Hilmi; Karahan, Nermin; Mungan, Tamer; Delibas, Namik

doi:10.1111/j.1440-1681.2007.04596.x

Protective effects of vitamins C and E against endometrial damage and oxidative stress in fluoride intoxication

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Guney M., Oral B., Demirin H., Karahan N., Mungan T., Delibas N.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.34, pp.467-474, 2007 (SCI-Expanded)

Publication Type: Article / Article
Volume: 34
Publication Date: 2007
Doi Number: 10.1111/j.1440-1681.2007.04596.x
Journal Name: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.467-474
Süleyman Demirel University Affiliated: Yes

Abstract

1. Fluoride (F) is an essential trace element that has protective effects against bone mineral loss. However, it becomes toxic at higher doses and induces some adverse effects on a number of physiological functions, including reproduction. The aims of this study were to examine F-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of vitamins C and E against possible F-induced endometrial impairment in rats.