Protective effects of vitamins C and E against endometrial damage and oxidative stress in fluoride intoxication


Guney M., Oral B. , Demirin H., Karahan N. , Mungan T., Delibas N.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.34, pp.467-474, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1440-1681.2007.04596.x
  • Title of Journal : CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Page Numbers: pp.467-474

Abstract

1. Fluoride (F) is an essential trace element that has protective effects against bone mineral loss. However, it becomes toxic at higher doses and induces some adverse effects on a number of physiological functions, including reproduction. The aims of this study were to examine F-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of vitamins C and E against possible F-induced endometrial impairment in rats.