Adipose tissue indices predict prognosis in hodgkin lymphoma
Leukemia Research, cilt.138, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 138
- Basım Tarihi: 2024
- Doi Numarası: 10.1016/j.leukres.2024.107457
- Dergi Adı: Leukemia Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Veterinary Science Database
- Anahtar Kelimeler: Hodgkin lymphoma, prognosis, SAT SUVmax, Total abdominal adipose tissue
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Introduction background: This study evaluated the impact of adipose tissue indices on prognosis of HL. Methods: Fifty-five patients with newly diagnosed Hodgkin Lymphoma were evaluated retrospectively for association with adipose tissue indices (total abdominal tissue volume, radiodensity, subcutaneous and visceral adipose tissue SUVmax value and prognostic factors for Hodgkin Lymphoma such as IPS-3, IPS-7, stage, sedimentation, progression free and overall survival. Results: For IPS-3, SAT SUVmax and TAAT radiodensity were significantly increased in high-risk patients (2and 3) compared to group 0 and 1. For IPS-7, total abdominal adipose volume was significantly decreased in high-risk patients, SAT SUVmax significantly increased in high-risk patients and decreased in low-risk patients. In addition, SAT SUVmax was significantly increased in patients with high sedimentation rate, with B symptoms and who passed away during follow-up. SAT SUVmax showed moderate positive correlation with sedimentation, IPS-3, IPS-7, and stage. In addition, it was observed that TAAT radiodensity and SAT SUVmax were significantly better for determining prognosis than other adipose tissue indices. Roc analysis showed that the diagnostic value of all adipose tissue indices in predicting IPS-3 and IPS-7 prognoses were statistically significant. Conclusion: SAT SUVmax and TAAT radiodensity were two new and independent markers with diagnostic value in predicting prognosis.