Modulator role of infliximab and methotrexate through the transient receptor potential melastatin 2 (TRPM2) channel in neutrophils of patients with rheumatoid arthritis: a pilot study


DOĞRU A. , NAZIROĞLU M. , Cig B.

ARCHIVES OF MEDICAL SCIENCE, cilt.15, ss.1415-1424, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 15 Konu: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5114/aoms.2018.79485
  • Dergi Adı: ARCHIVES OF MEDICAL SCIENCE
  • Sayfa Sayıları: ss.1415-1424

Özet

Introduction: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease causing symmetric polyarthritis. In this study, we aimed to investigate the effects of infliximab (INF) and methotrexate (MTX) on apoptosis, oxidative stress, and calcium signaling in the neutrophils of RA patients.