The effect of G-CSF and Teicoplanin in an experimental MRSA graft infection in mice


Agalar C., Eroglu E., Sari M., Sari A., Agalar F.

Eurosurgery 2000 Meeting, İstanbul, Türkiye, 21 - 24 Haziran 2000, ss.1-5 identifier

  • Cilt numarası:
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.1-5

Özet

G-CSF and Teicoplanin were studied in an experimental methicilline resistant staphylococcal graft infection model. An incision in 2 cm in length and a cavity in 2x2 cm in length was performed. Polypropylene mesh and MRSA solution of 0.1 mi of 10(8) CFU/ml were used. G-CSF or teicoplanin was applied systemically or locally in different settings. Three days from the operation incisions were examined for a possible infection. Under sterile conditions meshes were removed. Following one minute vortexing, dilution scheme was performed. When the wounds were examined it was seen that there were symptoms of wound infection in all groups except group VIII, In group VIII MRSA was isolated in 7 events with a colony count below 10(3), G-CSF could not prevent the development of wound infection, but Teicoplanin decreased the numbers of colony forming units of MRSA, and prevents wound infection in this MRSA wound infection model.