Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation


Kilicoglu O., KARA Ü., ÖZGENÇ E., ATLIHAN GÜNDOĞDU E.

APPLIED RADIATION AND ISOTOPES, vol.188, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 188
  • Publication Date: 2022
  • Doi Number: 10.1016/j.apradiso.2022.110364
  • Journal Name: APPLIED RADIATION AND ISOTOPES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chemical Abstracts Core, Chimica, Compendex, EMBASE, Food Science & Technology Abstracts, INSPEC, MEDLINE, Pollution Abstracts
  • Keywords: Covid-19, Monte Carlo simulation, Relative dose distribution, Gamma radiation emitter, Tc-99m, BIOACTIVE GLASSES, RADIATION, THERAPY, GAMMA, INFECTIONS
  • Süleyman Demirel University Affiliated: Yes

Abstract

Monte Carlo simulation method and Nuclear Medicine MIRD method were used to evaluate the effect of ra-diopharmaceuticals on Covid-19 disease. The mean absorbed organ dose in the target organ and gamma radi-ation emitter attenuation properties such as linear attenuation coefficients, energy absorption build-up factors (EABF), exposure build-up factors (EBF), and relative dose distributions (RDD) were examined. The results showed that radiopharmaceuticals containing gamma radiation emitters which are densely ionizing charged particles induced membrane damage and produced protein damage.