Combined PK-PD Model for 6-MP, MTX, and VCR Treatment in Childhood ALL Çocukluk Ça?gi ALL'de 6-MP, MTX ve VCR Tedavisi için Birleşik PK-PD Modeli
34th Signal Processing and Communications Applications Conference, SIU 2026, İstanbul, Türkiye, 7 - 10 Temmuz 2026, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Doi Numarası: 10.1109/siu71813.2026.11637041
- Basıldığı Şehir: İstanbul
- Basıldığı Ülke: Türkiye
- Anahtar Kelimeler: multi-drug chemotherapy, pediatric ALL, personelized dose optimization, PK-PD modeling
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
This study presents an integrated pharmacokinetic-pharmacodynamic (PK-PD) modeling framework for multi-drug chemotherapy used in pediatric Acute Lymphoblastic Leukemia (ALL). The model addresses the pharmacological effects of three commonly used drugs (6-mercaptopurine (6-MP), methotrexate (MTX), and vincristine (VCR)) simultaneously within a unified mathematical structure. For each drug, PK models describing absorption, distribution, metabolism, and elimination processes are combined under a drug effect function and integrated into the overall system. The model predicts hematological responses based on white blood cell (WBC) and absolute neutrophil count (ANC), as well as vincristine-induced peripheral neuropathy (VIPN) indicators. The simulation results demonstrate treatment response by capturing interactions between drugs and patient-specific variables across a four-phase treatment protocol, and provide a computational basis for personalized dose optimization in pediatric ALL treatment.