COVID-19-associated multisystem inflammatory syndrome in children: Experiences of three centres in Turkey


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SALMAN H. , Aslan N., AKÇAM M. , ARSLAN M. , Akkuzu E., YILMAZ KESKİN E. , ...More

MODERN RHEUMATOLOGY, vol.32, no.2, pp.460-466, 2022 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.1093/mr/roab042
  • Title of Journal : MODERN RHEUMATOLOGY
  • Page Numbers: pp.460-466
  • Keywords: COVID-19, gastrointestinal, Kawasaki disease, multisystem inflammatory syndrome in children, pandemic, MIS-C, COVID-19, INFECTION

Abstract

Background The pathogenesis and clinical manifestations of the multisystem inflammatory syndrome in children (MIS-C) has not yet been fully elucidated and there is no clear consensus on its treatment yet. Objectives To evaluate our patients diagnosed with MIS-C and present them to the literature in order to contribute to the better understanding of this new disease, which entered paediatric practice with the SARS-CoV-2 peak. Methods In this study, 17 MIS-C cases diagnosed according to the Centers for Disease Control and Prevention criteria were included. Results Of the patients, 7 (41.2%) had a comorbidity. Gastrointestinal system involvement was the most prominent in the patients (70.6%). Laparotomy was performed in 3 patients due to acute abdomen. Two patients had neurological involvement. Of the patients, 15 (88.2%) received intravenous immunoglobulin and 13 (76.5%) received both intravenous immunoglobulin and methylprednisolone. Two patients received invasive mechanical ventilation and 4 patients received high flow rate nasal cannula oxygen therapy. One of our patients who needed invasive mechanical ventilation and high vasoactive-inotrope support died despite all supportive treatments including plasmapheresis and extracorporeal membrane oxygenation. Conclusions MIS-C picture can have a fatal course and may present with severe gastrointestinal and neurological signs. Unnecessary laparotomy should be avoided.