Investigation of the Antibacterial Activity and Antiproliferative Properties of Ag Nanoparticles Synthesized Using Lavandula angustifolia Sevtopolis Extract against Prostate Cancer Cell Lines
Micro and Nanosystems, cilt.17, sa.3, ss.225-231, 2025 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 3
- Basım Tarihi: 2025
- Doi Numarası: 10.2174/0118764029351072250106052955
- Dergi Adı: Micro and Nanosystems
- Derginin Tarandığı İndeksler: Scopus, Compendex
- Sayfa Sayıları: ss.225-231
- Anahtar Kelimeler: Ag nanoparticles, antibacterial activity, antiproliferative activity, biosynthesis, green chemistry, Lavandula angustifolia Sevtopolis
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Introduction: In this study, silver nanoparticles (AgNPs) were synthesized using Lavandula angustifolia Sevtopolis (LA Sevtapolis) plant extract without using any reducing or stabilizing agent. Methods: The morphologies, optical properties, and crystallinities of the prepared AgNPs were determined using scanning electron microscopy, UV-visible spectroscopy, and X-ray diffraction. Results: The antibacterial activities of the synthesized AgNPs against some gram-negative and gram-positive bacterial species were investigated. The lowest effect was observed against the Gram-positive B. cereus ATCC 11778 with a concentration of 0.0375 µg/mL. Additionally, the toxic effect on the human normal cell line HEK-293T and the antiproliferative activity against the prostate (PC3) cancer cell line were examined. The IC50 values of AgNPs against PC3 and HEK-293T cells were found to be 4.72 µL/mL and 6.838 µL/mL, respectively. Conclusion: In conclusion, due to their antiproliferative and antibacterial activities, AgNPs synthesized using LA Sevtopolis extract were found to have potential applications in various biomedical fields.