Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymes in vitro

ALICIGÜZEL Y., Ozdem S., DEMİR A. Y. , ÜNAL F., Kumbul D., Ozdem S., ...More

REDOX REPORT, vol.6, no.3, pp.153-154, 2001 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1179/135100001101536256
  • Journal Name: REDOX REPORT
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.153-154


To investigate the possible role of oxygen free radicals and oxidant stress in the toxic effects of phenoxyherbicides. we studied the in vitro effect of 4-chlorophenoxyacetic acid (4-CPA) on various human erythrocyte antioxidant enzymes, namely glucose-6-phosphate dehydrogenase, catalase, selenium-dependent glutathione peroxidase, glutathione reductase and Cu/Zn-superoxide dismutase. 4-CPA added in a dose of 1 ppm to human erythrocytes for 1 h caused a significant reduction in glucose-6-phosphate dehydrogenase (P <0.001) and catalase (P <0.001) activities, but did not significantly affect the activities of other enzymes. Such selective inactivation of specific erythrocyte antioxidant enzymes may play a role in the toxic effects of phenoxyherbicides.