Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymes in vitro

ALICIGÜZEL Y., Ozdem S., DEMİR A. Y. , ÜNAL F., Kumbul D. , Ozdem S., ...Daha Fazla

REDOX REPORT, cilt.6, sa.3, ss.153-154, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Konu: 3
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1179/135100001101536256
  • Dergi Adı: REDOX REPORT
  • Sayfa Sayıları: ss.153-154


To investigate the possible role of oxygen free radicals and oxidant stress in the toxic effects of phenoxyherbicides. we studied the in vitro effect of 4-chlorophenoxyacetic acid (4-CPA) on various human erythrocyte antioxidant enzymes, namely glucose-6-phosphate dehydrogenase, catalase, selenium-dependent glutathione peroxidase, glutathione reductase and Cu/Zn-superoxide dismutase. 4-CPA added in a dose of 1 ppm to human erythrocytes for 1 h caused a significant reduction in glucose-6-phosphate dehydrogenase (P <0.001) and catalase (P <0.001) activities, but did not significantly affect the activities of other enzymes. Such selective inactivation of specific erythrocyte antioxidant enzymes may play a role in the toxic effects of phenoxyherbicides.