In this study, an adaptive network-based fuzzy inference system (ANFIS) approach is presented for modeling of high-strength concrete under uniaxial loading. The ANFIS approach applied to test the data of concrete cylinder test is available in the literature. In this paper, the stress-strain behavior of high-strength concrete subjected to axial load is obtained by using the ANFIS model. It is shown that the present model can predict the stress-strain behavior of concrete accurately by taking into account the effective parameters. The advantage of the proposed approach is that the stress-strain behavior of high-strength concrete can be predicted easily. The results of ANFIS approach are compared with the analytical models given in various studies concerning cylinder tests. The ANFIS approach results given show a good agreement with the experimental results.