The use of Resistograph for the purpose of nondestructive evaluation of certain properties of standing trees and wooden materials has increased in recent years. The resistance to penetration of a fine drill bit is measured and recorded by the device. A number of properties of the wood can be assessed by the amplitude values obtained from the Resistograph. The aim of this study was to assess the utility of the IML-Resistograph F 500 as a nondestructive tool for estimating spruce wood density using the amplitude data generated and the application of statistical modeling. Wood density data were determined using a volumetric method and were compared with the density data generated by the model. In this model, amplitude was used as an independent variable and the dependent variable for experimental purposes was wood density. No statistical difference (P = 0.176 > 0.05; 95% confidence level) was found between the groups. Moisture content was added as second independent variable and a second model was built. The results demonstrated that wood density can be estimated nondestructively using Resistograph data from lumber and/or large wooden materials, but more comprehensive models are required for the practical use of the device in the forest products industry.