The efficacy of single-dose 5-fluorouracil therapy in experimental caustic esophageal burn

DUMAN L., BÜYÜKYAVUZ B. İ., ALTUNTAS I., GOKCIMEN A., CEYHAN L., DARICI H., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.46, no.10, pp.1893-1897, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 10
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jpedsurg.2011.03.001
  • Journal Name: JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1893-1897
  • Süleyman Demirel University Affiliated: Yes

Abstract

Introduction: Accidental ingestion of caustic substances may cause serious problems in children. Approximately 20% of caustic ingestions result in esophageal stricture formation, resulting from excessive collagen synthesis to the extracellular matrix by fibroblasts. Recent studies showed that a single application of 5-fluorouracil (5-FU) is a very effective inhibitor of fibroblast proliferation and differentiation for prolonged periods. Using an experimental model, we investigated the efficacy of single-dose 5-FU on stricture formation after caustic esophageal burn.