The efficacy of single-dose 5-fluorouracil therapy in experimental caustic esophageal burn

DUMAN, Levent; BÜYÜKYAVUZ, Behçet; ALTUNTAS, Irfan; GOKCIMEN, Alpaslan; CEYHAN, Levent; DARICI, Hakan; AYLAK, Firdevs; TOMRUK, Önder

doi:10.1016/j.jpedsurg.2011.03.001

The efficacy of single-dose 5-fluorouracil therapy in experimental caustic esophageal burn

DUMAN L., BÜYÜKYAVUZ B. İ., ALTUNTAS I., GOKCIMEN A., CEYHAN L., DARICI H., ...Daha Fazla

JOURNAL OF PEDIATRIC SURGERY, cilt.46, sa.10, ss.1893-1897, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 46 Sayı: 10
Basım Tarihi: 2011
Doi Numarası: 10.1016/j.jpedsurg.2011.03.001
Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1893-1897
Süleyman Demirel Üniversitesi Adresli: Evet

Özet

Introduction: Accidental ingestion of caustic substances may cause serious problems in children. Approximately 20% of caustic ingestions result in esophageal stricture formation, resulting from excessive collagen synthesis to the extracellular matrix by fibroblasts. Recent studies showed that a single application of 5-fluorouracil (5-FU) is a very effective inhibitor of fibroblast proliferation and differentiation for prolonged periods. Using an experimental model, we investigated the efficacy of single-dose 5-FU on stricture formation after caustic esophageal burn.