The efficacy of single-dose 5-fluorouracil therapy in experimental caustic esophageal burn


DUMAN L. , BÜYÜKYAVUZ B. İ. , ALTUNTAS I., GOKCIMEN A., CEYHAN L., DARICI H., ...Daha Fazla

JOURNAL OF PEDIATRIC SURGERY, cilt.46, ss.1893-1897, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 46 Konu: 10
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.jpedsurg.2011.03.001
  • Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
  • Sayfa Sayıları: ss.1893-1897

Özet

Introduction: Accidental ingestion of caustic substances may cause serious problems in children. Approximately 20% of caustic ingestions result in esophageal stricture formation, resulting from excessive collagen synthesis to the extracellular matrix by fibroblasts. Recent studies showed that a single application of 5-fluorouracil (5-FU) is a very effective inhibitor of fibroblast proliferation and differentiation for prolonged periods. Using an experimental model, we investigated the efficacy of single-dose 5-FU on stricture formation after caustic esophageal burn.