Effects of Selenium and L-Carnitine on Oxidative Stress in Blood of Rat Induced by 2.45-GHz Radiation from Wireless Devices


GÜMRAL N. , NAZIROĞLU M. , Koyu A. , Ongel K., ÇELİK Ö. , SAYGIN M. , ...More

BIOLOGICAL TRACE ELEMENT RESEARCH, vol.132, pp.153-163, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 132
  • Publication Date: 2009
  • Doi Number: 10.1007/s12011-009-8372-3
  • Title of Journal : BIOLOGICAL TRACE ELEMENT RESEARCH
  • Page Numbers: pp.153-163
  • Keywords: 2.45 GHz electromagnetic radiation, Oxidative stress, Glutathione peroxidase, Vitamin C, L-carnitine, Selenium, VITAMIN-C, ELECTROMAGNETIC-FIELDS, LIPID-PEROXIDATION, CELLULAR PHONE, MICROWAVE, DAMAGE, ACID, PROTECTS, EXPOSURE, HEART

Abstract

The levels of blood lipid peroxidation, glutathione peroxidase, reduced glutathione, and vitamin C were used to follow the level of oxidative damage caused by 2.45 GHz electromagnetic radiation in rats. The possible protective effects of selenium and L-carnitine were also tested and compared to untreated controls. Thirty male Wistar Albino rats were equally divided into five groups, namely Groups A(1) and A(2): controls and sham controls, respectively; Group B: EMR; Group C: EMR + selenium, Group D: EMR + L-carnitine. Groups B-D were exposed to 2.45 GHz electromagnetic radiation during 60 min/day for 28 days. The lipid peroxidation levels in plasma and erythrocytes were significantly higher in group B than in groups A(1) and A(2) (p < 0.05), although the reduced glutathione and glutathione peroxidase values were slightly lower in erythrocytes of group B compared to groups A(1) and A(2). The plasma lipid peroxidation level in group A(2) was significantly lower than in group B (p < 0.05). Erythrocyte reduced glutathione levels (p < 0.01) in group B; erythrocyte glutathione peroxidase activity in group A(2) (p < 0.05), group B (p < 0.001), and group C (p < 0.05) were found to be lower than in group D. In conclusion, 2.45 GHz electromagnetic radiation caused oxidative stress in blood of rat. L-carnitine seems to have protective effects on the 2.45-GHz-induced blood toxicity by inhibiting free radical supporting antioxidant redox system although selenium has no effect on the investigated values.