Effects of Selenium and L-Carnitine on Oxidative Stress in Blood of Rat Induced by 2.45-GHz Radiation from Wireless Devices


GÜMRAL N. , NAZIROĞLU M. , Koyu A. , Ongel K., ÇELİK Ö. , SAYGIN M. , ...Daha Fazla

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.132, ss.153-163, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 132
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s12011-009-8372-3
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Sayfa Sayıları: ss.153-163

Özet

The levels of blood lipid peroxidation, glutathione peroxidase, reduced glutathione, and vitamin C were used to follow the level of oxidative damage caused by 2.45 GHz electromagnetic radiation in rats. The possible protective effects of selenium and L-carnitine were also tested and compared to untreated controls. Thirty male Wistar Albino rats were equally divided into five groups, namely Groups A(1) and A(2): controls and sham controls, respectively; Group B: EMR; Group C: EMR + selenium, Group D: EMR + L-carnitine. Groups B-D were exposed to 2.45 GHz electromagnetic radiation during 60 min/day for 28 days. The lipid peroxidation levels in plasma and erythrocytes were significantly higher in group B than in groups A(1) and A(2) (p < 0.05), although the reduced glutathione and glutathione peroxidase values were slightly lower in erythrocytes of group B compared to groups A(1) and A(2). The plasma lipid peroxidation level in group A(2) was significantly lower than in group B (p < 0.05). Erythrocyte reduced glutathione levels (p < 0.01) in group B; erythrocyte glutathione peroxidase activity in group A(2) (p < 0.05), group B (p < 0.001), and group C (p < 0.05) were found to be lower than in group D. In conclusion, 2.45 GHz electromagnetic radiation caused oxidative stress in blood of rat. L-carnitine seems to have protective effects on the 2.45-GHz-induced blood toxicity by inhibiting free radical supporting antioxidant redox system although selenium has no effect on the investigated values.