Cutaneous Leucocytoclastic Vasculitis Associated with Fluvoxamine

Eren I., Civi I., ŞAHİN M.

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, vol.18, no.4, pp.306-308, 2008 (SCI-Expanded) identifier identifier


Fluvoxamine is widely used in psychiatry practice in the treatment of depression, panic disorder, obsessive-compulsive disorder, and eating disorders. Leucocytoclastic vasculitis is a serious drug reaction that is characterized by immune complex deposition in the postcapillary venules. It usually presents as purpura on the lower extremities with or without systemic involvement. Here, we report fluvoxamine induced leucocytoclastic vasculitis in a patient with obsessive compulsive disorder. Antidepressants have rarely been associated with leucocytoclastic vasculitis, and to the best of our knowledge vasculitis of any type has not previously been reported in association with fluvoxamine.