Serum Neopterin and TNF-alpha Levels in Psoriasis and Their Correlation with Disease Severity
TURKDERM-ARCHIVES OF THE TURKISH DERMATOLOGY AND VENEROLOGY, cilt.46, sa.1, ss.7-10, 2012 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 1
- Basım Tarihi: 2012
- Doi Numarası: 10.4274/turkderm.60243
- Dergi Adı: TURKDERM-ARCHIVES OF THE TURKISH DERMATOLOGY AND VENEROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.7-10
- Anahtar Kelimeler: Psoriasis, neopterin, TNF-alpha, IMMUNE ACTIVATION, THERAPY, MARKER
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Background and Design: Psoriasis is a T cell-mediated autoimmune skin disease characterized by hyperproliferation of keratinocytes and accumulation of activated T cells responding to a hitherto unidentified antigenic stimulus. Tumor necrosis factor-alpha (TNF-alpha) plays an essential role in the induction and maintenance of psoriatic lesion. Neopterin is a non-specific immunological marker of cellular immune activation, which is produced by human monocytes/macrophages as a result of interferon-gamma secretion by activated T lymphocytes. The aim of the presented study was to determine the levels of serum neopterin and TNF-alpha in psoriatic patients and to evaluate whether Psoriasis Area correlated with Severity Index (PASI) and serum levels of neopterin and TNF-alpha.