EVALUATION OF AMINO ACID PROFILE IN SERUM OF PATIENTS WITH COVID-19 FOR PROVIDING A NEW TREATMENT STRATEGY PROCENA AMINOKISELINSKOG PROFILA U SERUMU PACIJENATA SA COVID-19 ZA OBEZBE\IVANJE NOVE STRATEGIJE LE^ENJA

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Ozturk A., Bayraktar N., Bayraktar M., IBRAHIM B., Bozok T., Ceylan M. R.

Journal of Medical Biochemistry, cilt.41, sa.4, ss.526-533, 2022 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5937/jomb0-37514
  • Dergi Adı: Journal of Medical Biochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.526-533
  • Anahtar Kelimeler: amino acid, Covid-19, Sars-CoV-2, treatment strategy, CORONAVIRUS DISEASE 2019, RESISTANCE, ARGININE, LEUCINE, CELLS
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Süleyman Demirel Üniversitesi Adresli: Evet

Özet

© 2022 Sciendo. All rights reserved.Background: Amino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID-19 patients was evaluated to determine a new treatment strategy. Methods: The amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined. The amino acid profiles of the participants were screened by LC-MS/MS. Results: Compared with the control group, serum levels of 27 amino acids increased in the patient group. Alpha-aminopimelic acid, sarcosine, and hydroxyproline amino acids were considerably higher in the control group than in the patient group (p<0.0001). There was no notable difference among control group and the case group for 13 amino acids (p≥0.05). A significant positive correlation was seen among the control and the patient groups in the mean amino acid values (r=0.937; p<0.0001). Conclusions: These results postulated a clear picture on the serum levels of amino acid in the COVID-19 patients. Serum amino acids measured in hospitalized COVID-19 patients can explain the patient’s metabolic status during the disease.