Bone mineral density of the spine and femur in early postmenopausal Turkish women with endemic skeletal fluorosis

Yildiz M., Akdogan M., Tamer N., Oral B.

CALCIFIED TISSUE INTERNATIONAL, vol.72, no.6, pp.689-693, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 6
  • Publication Date: 2003
  • Doi Number: 10.1007/s00223-002-2097-z
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.689-693
  • Süleyman Demirel University Affiliated: No


The aim of this prospective, comparative study was to investigate the bone mineral density (BMD) changes in a group of early postmenopausal Turkish women with endemic skeletal fluorosis and to study effects of endemic fluorosis on BMD. Bone mineral density of L-2-L-4 vertebra, femur neck, femur trochanter, and Ward's triangle were measured in 45 female patients with endemic skeletal fluorosis and 41 age-matched controls by dual X-ray absorbtiometry (DXA). The BNID of L-2-L-4 vertebra and Ward's triangle were higher in the endemic fluorosis group than in the control C Group (P < 0.001). Patients with endemic fluorosis had higher femur neck and femur trochanter BMDs than did controls (P < 0.01 and P < 0.05, respectively). There was a positive correlation between serum fluoride content and BNID at the spine (r = 0.345, P = 0.001), femoral neck (r = 0.274, P = 0.011), Ward's triangle (r = 0.295. P = 0.006), and trochanter (r = 0.217, P = 0.045). In conclusion, higher bone mineral density levels were seen in early postmenopausal women with endemic skeletal fluorosis. BNID measurement is a tool in the diagnosis and management of this preventable crippling disease.