Bone mineral density of the spine and femur in early postmenopausal Turkish women with endemic skeletal fluorosis

Yildiz M., Akdogan M., Tamer N., Oral B.

CALCIFIED TISSUE INTERNATIONAL, cilt.72, ss.689-693, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 72 Konu: 6
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1007/s00223-002-2097-z
  • Sayfa Sayıları: ss.689-693


The aim of this prospective, comparative study was to investigate the bone mineral density (BMD) changes in a group of early postmenopausal Turkish women with endemic skeletal fluorosis and to study effects of endemic fluorosis on BMD. Bone mineral density of L-2-L-4 vertebra, femur neck, femur trochanter, and Ward's triangle were measured in 45 female patients with endemic skeletal fluorosis and 41 age-matched controls by dual X-ray absorbtiometry (DXA). The BNID of L-2-L-4 vertebra and Ward's triangle were higher in the endemic fluorosis group than in the control C Group (P < 0.001). Patients with endemic fluorosis had higher femur neck and femur trochanter BMDs than did controls (P < 0.01 and P < 0.05, respectively). There was a positive correlation between serum fluoride content and BNID at the spine (r = 0.345, P = 0.001), femoral neck (r = 0.274, P = 0.011), Ward's triangle (r = 0.295. P = 0.006), and trochanter (r = 0.217, P = 0.045). In conclusion, higher bone mineral density levels were seen in early postmenopausal women with endemic skeletal fluorosis. BNID measurement is a tool in the diagnosis and management of this preventable crippling disease.