Sitagliptin and Acute Pancreatitis: Cases and Literature Review

Kale Koroglu B., Songur Y., Ersoy I. H., Koroglu M., Akin M., Tamer M. N.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.32, no.3, pp.859-864, 2012 (SCI-Expanded) identifier identifier


Acute pancreatitis is the rapid onset inflammation of the pancreas. Medications are rare but important and rising cause of acute pancreatitis and account for approximately 2% of all cases. Sitagliptin is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of patients with type 2 diabetes mellitus and acts by increasing active incretin hormone concentrations. Adverse effects including constipation, nausea, nasopharyngitis, urinary tract infection and dizziness were reported. We reported a case with acute pancreatitis that seems to be induced by sitagliptin.