The role of High Mobility Group Box 1 (HMGB1) in colorectal cancer

Suren D., Yildirim M., Demirpence O., KAYA V. , Alikanoglu A. S. , Bulbuller N., ...More

MEDICAL SCIENCE MONITOR, vol.20, pp.530-537, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2014
  • Doi Number: 10.12659/msm.890531
  • Title of Journal : MEDICAL SCIENCE MONITOR
  • Page Numbers: pp.530-537


Background: HMGB1, the most important member of the high mobility group box protein family, is a nuclear protein with different functions in the cell; it has a role in cancer progression, angiogenesis, invasion, and metastasis development. We studied the expression of HMGB1 and whether it is a prognostic factor in colorectal carcinoma.