Synergic prooxidant, apoptotic and TRPV1 channel activator effects of alpha-lipoic acid and cisplatin in MCF-7 breast cancer cells

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Nur G., NAZIROĞLU M., Deveci H. A.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, vol.37, no.6, pp.569-577, 2017 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 37 Issue: 6
• Publication Date: 2017
• Doi Number: 10.1080/10799893.2017.1369121
• Journal Name: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.569-577
• Süleyman Demirel University Affiliated: Yes

Abstract

Background: Resistance to cisplatin (Cisp) in the treatment of breast cancer is a major obstacle. Alpha-lipoic acid (ALA) has both antioxidant and oxidant properties. ALA has been used on stimulation mechanisms of apoptosis and oxidative stress in the treatment of cancer with a combination of chemotherapeutic agents, although its role on molecular mechanisms in the cancer cells has not been clarified yet. The aim of this study was to evaluate if a combination therapy of ALA with Cisp can alter the effect of this chemotherapy drug in the MCF-7 breast cancer cells.