This study aimed to evaluate color masking effect from treatments with resin infiltrant and two different remineralization agents applied with microabrasion to anterior teeth with developmental enamel defects. The incisors of patients aged 8-17 were evaluated. The study involved two groups including fluorosis (Group 1) and hypomineralization (Group 2) cases. These two groups were further divided based on the treatment received: Group A: Icon (R), Group B: Opalustre (R)+Clinpro White Varnish (R), and Group C: Opalustre (R)+Tooth Mousse (R). The spectrophotometric values were recorded. Furthermore, the L* and Delta E values were evaluated by repeated measures of ANOVA. The largest increase in L* values over time after treatment was in Group 1A, followed by Group 1C and Group 1B. The largest increase in Delta E values over time after treatment was in Group 1A. Clinically observable difference was achieved as a result of all treatment groups. Especially resin infiltration treatment has been found to be more effective in teeth with fluorosis.