Doxorubicin for prevention of epineurial fibrosis in a rat sciatic nerve model: outcome based on gross postsurgical, histopathological, and ultrastructural findings Laboratory investigation

Albayrak, Baki; İSMAİLOĞLU, Özgür; Ilbay, Konuralp; Yaka, Umut; TANRIÖVER, GAMZE; Gorgulu, Askin; DEMİR, NECDET

doi:10.3171/2009.9.spine09407

Doxorubicin for prevention of epineurial fibrosis in a rat sciatic nerve model: outcome based on gross postsurgical, histopathological, and ultrastructural findings Laboratory investigation

Albayrak B. S., İSMAİLOĞLU Ö., Ilbay K., Yaka U., TANRIÖVER G., Gorgulu A., ...Daha Fazla

JOURNAL OF NEUROSURGERY-SPINE, cilt.12, sa.3, ss.327-333, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 12 Sayı: 3
Basım Tarihi: 2010
Doi Numarası: 10.3171/2009.9.spine09407
Dergi Adı: JOURNAL OF NEUROSURGERY-SPINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.327-333
Süleyman Demirel Üniversitesi Adresli: Evet

Özet

Object. Epineural fibrosis may complicate peripheral nerve surgeries and currently is considered as one of the main factors responsible for failed surgeries. The authors investigated the postoperative antiscarring effects of topically applied doxorubicin (DXR) on rat sciatic nerves.