Diagnostic ultrasound treatment increases the bone fracture-healing rate in an internally fixed rat femoral osteotomy model

Heybeli N., Yesildag A., Oyar O., Gulsoy U., Tekinsoy M., Mumcu E.

JOURNAL OF ULTRASOUND IN MEDICINE, vol.21, no.12, pp.1357-1363, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 12
  • Publication Date: 2002
  • Doi Number: 10.7863/jum.2002.21.12.1357
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1357-1363
  • Süleyman Demirel University Affiliated: No


Objective. To investigate the healing effects of diagnostic ultrasound in a standardized rat femur fracture model. Methods. Thirty-two male rats aged 14 weeks were used, and each rat's right femur was osteotomized and stabilized under anesthesia, The rats were then divided into 4 groups, Five days after surgery, ultrasound was applied every fifth day with diagnostic sonographic equipment and a probe with a 7.5-MHz frequency and 11.8-mW/cm(2) total output intensity for 10 minutes in each session. Ultrasound was applied 8 times in group A, 3 times in group 3, and only once in group C, Ultrasound was not applied to sham-operated group D. Healing and callus formation of the rats' femur fractures were evaluated by radiography and dual-energy x-ray absorptiometry. Results. Dual-energy x-ray absorptiometric and radiographic results showed that the ultrasound therapy accelerated the fracture healing. Radiographically, groups A and B showed better fracture healing than groups C and D, Ultrasound exposure increased both the whole-bone mineral density and the density at the fracture region, increasing in parallel with the exposure period. Conclusions. This study confirms the previously shown efficacy of low-intensity ultrasonic stimulation in acceleration of the normal fracture repair process even when performed with a diagnostic sonographic device.