Effects of vascular endothelial growth factor on nerve regeneration in acellular nerve grafts

Rovak J., Mungara A., Aydin M., Cederna P.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY, vol.20, no.1, pp.53-58, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1055/s-2004-818050
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.53-58
  • Süleyman Demirel University Affiliated: No


The purpose of this study was to evaluate the effects of human recombinant vascular endothelial growth factor (VEGF-165) on peripheral nerve axonal sprouting and elongation following peripheral nerve injury and repair. Two-centimeter nerve gaps were created in rat peroneal nerves and repaired with either peripheral nerve autografts, acellular peripheral nerve isografts, or VEGF-165-treated acellular peripheral nerve isografts. Four months postoperatively, the peroneal nerves were harvested and histomorphometric analysis was performed. The reinnervated extensor digitorum longus (EDL) muscles were harvested and weighed.