Spinal morphine administration reduces the fatty acid contents in spinal cord and brain by increasing oxidative stress
NEUROCHEMICAL RESEARCH, cilt.32, sa.1, ss.19-25, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 1
- Basım Tarihi: 2007
- Doi Numarası: 10.1007/s11064-006-9217-5
- Dergi Adı: NEUROCHEMICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.19-25
- Anahtar Kelimeler: morphine, fatty, acids, brain, lipid peroxidation, spinal cord, glutathione, VITAMIN-E, LIVER-TISSUES, CANCER PAIN, DRUGS, RATS, NEUROTOXICITY, SELENIUM, RELEASE, PRODUCT, DAMAGE
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
It is well known that oxidative stress damages bimolecules such as DNA and lipids. No study is available on the morphine-induced oxidative damage and fatty acids changes in brain and spinal tissues. The aim of this work was to determine the effects of morphine on the concentrations and compositions of fatty acid in spinal cord segments and brain tissues in rabbits as well as lipid peroxidation (LP) and glutathione (GSH) levels in cortex brain.