Spinal morphine administration reduces the fatty acid contents in spinal cord and brain by increasing oxidative stress


Ozmen I., Naziroglu M., Alici H. A. , Sahin F., Cengiz M., Eren I.

NEUROCHEMICAL RESEARCH, vol.32, no.1, pp.19-25, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1007/s11064-006-9217-5
  • Title of Journal : NEUROCHEMICAL RESEARCH
  • Page Numbers: pp.19-25

Abstract

It is well known that oxidative stress damages bimolecules such as DNA and lipids. No study is available on the morphine-induced oxidative damage and fatty acids changes in brain and spinal tissues. The aim of this work was to determine the effects of morphine on the concentrations and compositions of fatty acid in spinal cord segments and brain tissues in rabbits as well as lipid peroxidation (LP) and glutathione (GSH) levels in cortex brain.