Spinal morphine administration reduces the fatty acid contents in spinal cord and brain by increasing oxidative stress

Ozmen I., Naziroglu M., Alici H. A., Sahin F., Cengiz M., Eren İ.

NEUROCHEMICAL RESEARCH, vol.32, no.1, pp.19-25, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1007/s11064-006-9217-5
  • Journal Name: NEUROCHEMICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.19-25
  • Keywords: morphine, fatty, acids, brain, lipid peroxidation, spinal cord, glutathione, VITAMIN-E, LIVER-TISSUES, CANCER PAIN, DRUGS, RATS, NEUROTOXICITY, SELENIUM, RELEASE, PRODUCT, DAMAGE
  • Süleyman Demirel University Affiliated: Yes

Abstract

It is well known that oxidative stress damages bimolecules such as DNA and lipids. No study is available on the morphine-induced oxidative damage and fatty acids changes in brain and spinal tissues. The aim of this work was to determine the effects of morphine on the concentrations and compositions of fatty acid in spinal cord segments and brain tissues in rabbits as well as lipid peroxidation (LP) and glutathione (GSH) levels in cortex brain.