Increased Caspase-3 Immunoreactivity of Erythrocytes in STZ Diabetic Rats

Firat U., KAYA S., Cim A., BÜYÜKBAYRAM H., GÖKALP O., Dal M. S., ...More

EXPERIMENTAL DIABETES RESEARCH, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2012
  • Doi Number: 10.1155/2012/316384
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Süleyman Demirel University Affiliated: Yes


Eryptosis is a term to define apoptosis of erythrocytes. Oxidative stress and hyperglycemia, both of which exist in the diabetic intravascular environment, can trigger eryptosis of erythrocytes. In this experimental study, it is presented that the majority of erythrocytes shows caspase-3 immunoreactivity in streptozocin- (STZ)-induced diabetic rats. Besides that, caspase-3 positive erythrocytes are aggregated and attached to vascular endothelium. In conclusion, these results may start a debate that eryptosis could have a role in the diabetic complications.