Increased Caspase-3 Immunoreactivity of Erythrocytes in STZ Diabetic Rats


Firat U., KAYA S., Cim A., BÜYÜKBAYRAM H., GÖKALP O., Dal M. S. , ...More

EXPERIMENTAL DIABETES RESEARCH, 2012 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2012
  • Doi Number: 10.1155/2012/316384
  • Journal Name: EXPERIMENTAL DIABETES RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus

Abstract

Eryptosis is a term to define apoptosis of erythrocytes. Oxidative stress and hyperglycemia, both of which exist in the diabetic intravascular environment, can trigger eryptosis of erythrocytes. In this experimental study, it is presented that the majority of erythrocytes shows caspase-3 immunoreactivity in streptozocin- (STZ)-induced diabetic rats. Besides that, caspase-3 positive erythrocytes are aggregated and attached to vascular endothelium. In conclusion, these results may start a debate that eryptosis could have a role in the diabetic complications.