Increased Caspase-3 Immunoreactivity of Erythrocytes in STZ Diabetic Rats

Firat U., KAYA S., Cim A., BÜYÜKBAYRAM H., GÖKALP O., Dal M. S. , ...Daha Fazla

EXPERIMENTAL DIABETES RESEARCH, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası:
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1155/2012/316384


Eryptosis is a term to define apoptosis of erythrocytes. Oxidative stress and hyperglycemia, both of which exist in the diabetic intravascular environment, can trigger eryptosis of erythrocytes. In this experimental study, it is presented that the majority of erythrocytes shows caspase-3 immunoreactivity in streptozocin- (STZ)-induced diabetic rats. Besides that, caspase-3 positive erythrocytes are aggregated and attached to vascular endothelium. In conclusion, these results may start a debate that eryptosis could have a role in the diabetic complications.