The aim of this study was to evaluate the effect of CNC routing, using different parameters with the Taguchi experimental design, on the surface quality of various wooden (pine, spruce, and beech) edge-glued panels (EGP). The study evaluated five processing parameters: cutting direction, cutting depth, cutting width, feed rate, and spindle rotation speed, and their effects on surface roughness on pine, spruce, and beech EGP. Based on the results of statistical analysis of the burr surface roughness values, the mentioned parameters affected panels at varying levels. It was seen that the parameters were only responsible for similar to 34% (R-z) of the roughness on the surface of pine EGP, similar to 49% (R-z) of spruce EGP, and similar to 27% (R-q) of beech EGP. Statistically important parameters were as follows: cutting direction for pine, cutting depth (tip diameter) and feed rate for spruce, and cutting direction and feed rate for beech.