The effect of fixed-dose combination of valsartan and amlodipine on nighttime blood pressure in patients with non-dipper hypertension

ERDOGAN D., ICLI A., AKSOY F. , AKCAY S., YUCEL H., ERSOY I., ...More

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY, vol.44, no.5, pp.404-413, 2016 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.5543/tkda.2015.98250
  • Title of Journal : TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
  • Page Numbers: pp.404-413
  • Keywords: Amlodipine, ambulatory blood pressure, non-dipper, fixed dose combination, valsartan, DOUBLE-BLIND, CARDIOVASCULAR EVENTS, PARALLEL-GROUP, MONOTHERAPY, EFFICACY, THERAPY, RISK, TOLERABILITY, OPTIMIZATION, PREVENTION

Abstract

Objective: Failure to decrease blood pressure (BP) during the night is associated with higher cardiovascular (CV) morbidity and mortality. There is strong evidence that fixed-dose combinations (FDCs) of antihypertensive agents are associated with significant improvement and non-significant adverse effects. The aim of the present study was to evaluate whether FDC affected nocturnal BP favorably in patients with uncontrolled, non-dipper hypertension (HT).