Objective: The aim of this study was to examine the effect of pre-post deproteinization treatment with 5% sodium hypochloride on shear bond strength (sbs) of adhesive resin to primary, immature and mature permanent teeth enamel. Method: 30 teeth were used for each of primary, immature and mature permanent teeth groups. (totally 90). In control groups, enamel was etched for 60s with 37% phosphoric acid (3M) and rinsed for 10s (Procedure A). In experimental groups, deproteinization was applied. with 5% NaOCI solution for 120s before (Procedure D+A) and after acid-etching (Procedure A+D). Gluma Comfort Bond (Heraeus-Kulzei) and Charisma (Heraeus-Kulzer) composite resin were applied to etched enamel surfaces. Data were determined with Two-Way ANOVA and LSD Multiple Comparison Test (p<0.05). Results: SBS was significantly lower in primary and immature permanent teeth than mature permanent teeth (p<0.05). "Procedure A+D" statistically increased sbs values in primary and immature permanent teeth (p<0.05). Conclusion: Deproteinization after acid etching significantly enhanced the shear bond strength values in primary and immature permanent teeth.