Effect of Curcumin on Systemic T Helper 17 Cell Response; Gingival Expressions of Interleukin-17 and Retinoic Acid Receptor-Related Orphan Receptor gamma t; and Alveolar Bone Loss in Experimental Periodontitis

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BAKIR B., Ay Z., BÜYÜKBAYRAM H. İ., Doguc D. K., BAYRAM D., Candan I. A., ...More

JOURNAL OF PERIODONTOLOGY, vol.87, no.11, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 87 Issue: 11
• Publication Date: 2016
• Doi Number: 10.1902/jop.2016.150722
• Journal Name: JOURNAL OF PERIODONTOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Keywords: Alveolar bone loss, curcumin, interleukin-17, interleukin-23, periodontitis, Th17, TH17 CELLS, ANTIINFLAMMATORY AGENT, IL-17, AUTOIMMUNE, DISEASE, LIGAND, SITES, BETA, DIFFERENTIATION, PROGRESSION
• Süleyman Demirel University Affiliated: Yes

Abstract

Background: Curcumin has anti-inflammatory and antioxidant effects and is reported to have many biologic activities. The current study examines effect of curcumin on: 1) systemic T helper 17 (Th17) cell response; 2) gingival expressions of interleukin (IL)-17 and retinoic acid receptor-related orphan receptor (ROR) gamma t; and 3) alveolar bone loss (ABL) in experimental periodontitis.