Objective: Split-thickness skin grafting is a widely used technique for the coverage of skin defects. Surgeons using split-thickness skin grafts regularly face with the different dressing options. Yet, no ideal method for the appropriate dressing is present currently. Here, five different dressing materials were used for split thickness skin graft donor sites. Material and Methods: Twelve patients undergoing elective split-thickness skin grafting were included in the study. Povidone iodine, vaseline, paraffin, scarlet red, and cellulose were used. The donor site was imaginary divided into 5 equal pieces, and subsequently the materials were applied on these pieces adequately. Postoperative pain, inspection of the donor site, epithelization time, and patient comfort were assessed. Preoperative and postoperative photographs, postoperative wound healing and the histological examination of the donor site for each dressing were also evaluated in the study. Results: Cellulose was the most convenient material with regard to pain, comfort, and photographs. However, there was no significant difference according to the histopathologic evaluation of the donor sites after intervention. Conclusion: We, suggest that cellulose coated with petrolatum is a good alternative in split thickness skin graft donor sites. We highly recommend this material for better cosmetic results, even in larger areas, especially in elders.