Nucleoside diphosphate kinase (nm23 protein) expression in retinoblastoma

Bardak Y., Cekic O., Ayhan A., Gunalp I., Bulay O.

OPHTHALMIC RESEARCH, vol.32, pp.73-78, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32
  • Publication Date: 2000
  • Doi Number: 10.1159/000055593
  • Journal Name: OPHTHALMIC RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.73-78
  • Süleyman Demirel University Affiliated: No

Abstract

Forty-two enucleated eyes of 42 patients with unilateral retinoblastoma were studied histologically, including histochemically examiantion with anti-nm23 polyclonal antibody which does not recognise cDNA but its product. Primary tumours of>15 mm diameter with less evidence of apoptosis and with the most pleomorphic and anaplastic nuclei were associated with an increased risk of distant metastasis, but rosette formation did not discriminate. A high intensity of nm23 staining also indicated a tendency to meastasise, consistent with childhood neuroblastoma but in contrast to findings in carcinoma of the breast, colon and uterine cervix. Copyright (C) 2000 S. Karger AG. Basel.