Nucleoside diphosphate kinase (nm23 protein) expression in retinoblastoma

Bardak Y., Cekic O., Ayhan A., Gunalp I., Bulay O.

OPHTHALMIC RESEARCH, cilt.32, ss.73-78, 2000 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1159/000055593
  • Sayfa Sayıları: ss.73-78


Forty-two enucleated eyes of 42 patients with unilateral retinoblastoma were studied histologically, including histochemically examiantion with anti-nm23 polyclonal antibody which does not recognise cDNA but its product. Primary tumours of>15 mm diameter with less evidence of apoptosis and with the most pleomorphic and anaplastic nuclei were associated with an increased risk of distant metastasis, but rosette formation did not discriminate. A high intensity of nm23 staining also indicated a tendency to meastasise, consistent with childhood neuroblastoma but in contrast to findings in carcinoma of the breast, colon and uterine cervix. Copyright (C) 2000 S. Karger AG. Basel.