Follicular ADAMTS-1 and aggrecan levels in polycystic ovary syndrome


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Tola E. N. , Karatopuk D. , Koroglu N., ERGİN M., ORAL H. B.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.34, ss.811-816, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 34 Konu: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s10815-017-0913-7
  • Dergi Adı: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Sayfa Sayıları: ss.811-816

Özet

Purpose Polycystic ovary syndrome (PCOS) is the most common cause of ovulatory dysfunction and female infertility. The etiopathogenetic mechanisms of PCOS have been studied for many years, although exact causes remain unclear. It has been demonstrated that proteoglycan degradation by a disintegrin-like metalloproteinase with thrombospondin type motifs-1 (ADAMTS-1) is essential for ovulation and fertilization. The objective of our study is to analyze the levels of ADAMTS-1 and aggrecan in the follicular fluid (FF) of PCOS patients compared with normal ovulatory women and to determine whether these markers could be a predictor of in vitro fertilization (IVF) success in PCOS patients.