Objective: Pre-operative imaging characteristics of placental site trophoblastic tumor (PSTT) are variable and non-specific. Although magnetic resonance imaging (MRI), ultrasonography, chest CT/X-rays findings have been studied, the fluorine-18 fluorodeoxyglucose positron emission tomography/ computed tomography (F-18-FDG PET/CT) findings of PSTT have not been previously documented. We present the findings of a first case of PSTT evaluated by pre-operative (18)FDG PET/CT. A suspicious mass was biopsied and revealed PSTT in post-operative pathological examination. She was referred to the gynecology oncology department.The (18)FDG PET/CT scan revealed a 27x20mm laterally expanded lesion that showed increased F-18-FDG uptake (SUVmax :5.20) on the right isthmus of the uterus.The F-18-FDG PET/CT findings were in accordance with those from chest X-ray/s, CT and pelvic ultrasonography. A systematic, nerve sparing, paraaortic and pelvic lymph node dissection along with total hysterectomy and salpingoopherectomy was performed. The patient was discharged uneventfully. Conclusion: F-18-FDG PET/CT scan was able to identify the mass in the uterus which was shown by pathology to be PSTT. This finding of PET/CT was in accordance with other imaging techniques. Lymphatic mapping of (18)FDG PET/CT in this case of was also in accordance with surgery and pathology findings.