Pets are constantly taking toxic substances from the air, soil, water or feed. These toxic substances affect all organs and cause many important health problems. These toxins need to be removed from the body of the animals. Detoxification (detox) is a process of disposing of toxic substances by converting them into non-toxic substances. There are new detoxification products for cats and dogs made from aromatic plant extracts. There are many herbal products used in the traditional medicine field and considered to have detox effect, but these products may contain some substances that may have adverse effects also. The purpose of this project was to investigate the safety of these products on animal health. In this experiment, forty rats were randomly assigned to five groups (control, 20% cat detox, 100% cat detox, 20% dog detox, 100% dog detox). Water intake was increased 7-11% in detox groups when compared to control group except 20% cat detox group which was similar to the control group. The rats were healthy from the beginning to the end and animals had no complication. According to our result, 100% cat detox or 100% dog detox products could be consumed daily up to 100% without any adverse affect.