Some isotopes such as Iodine, are vital especially in medical science and thus production of those isotopes becomes important. In this study the cross sections of the Te-125(p,xn) reaction where iodine can be produced, were calculated for the 5.5-100.5 MeV energy range using TALYS-1.2 computer program. The calculated Te-125(p,xn) cross sections have been compared with the experimental Nuclear Reaction Data (EXFOR-Experimental Nuclear Reaction Data) obtained from the library and also results obtained by the ALICE/ASH code. It was seen that the agreement between all results is good and this reaction is an important way to produce iodine isotopes. (C) 2013 Elsevier Ltd. All rights reserved.