Molecular role of catalase on oxidative stress-induced Ca2+ signaling and TRP cation channel activation in nervous system


JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, vol.32, no.3, pp.134-141, 2012 (SCI-Expanded) identifier identifier identifier


Background: Catalase catalyzes the reduction of H2O2 to water and it can also remove organic hydroperoxides. Nervous system in body is especially sensitive to free radical damage due to rich content of easily oxidizible fatty acids and relatively low content of antioxidants including catalase. Recent studies indicate that reactive oxygen species actually target active channel function, in particular TRP channels. I review the effects of catalase on Ca2+ signaling and on TRP channel activation in neuroglial cells such as microglia and substantia nigra.