Controlled Release of Ibuprofen From Electrospun Biocompatible Nanofibers With In Situ QCM Measurements

Celik G., ÖKSÜZ A.

JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY, vol.52, no.1, pp.76-83, 2015 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1080/10601325.2014.978200
  • Title of Journal : JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
  • Page Numbers: pp.76-83

Abstract

A series of drug-incorporating electrospun biocompatible nanofibers were fabricated by using the electrospinning process. A hydrophobic drug (ibuprofen, IBU) was directly dissolved with biopolymer systems such as polyvinyl alcohol/plasma modified chitosan (PVA/PMCh), polyvinyl alcohol/chitosan (PVA/Ch) and cellulose acetate (CA) into an organic solvent prior to electrospinning. The release of IBU from drug-loaded electrospun fibers was monitored using a quartz crystal microbalance (QCM). The results were compared with utilizing UV/Vis spectroscopy results. The biocompatible fibers were Fourier transform infrared spectroscopy (FTIR). The IBU-loaded PVA/Ch and PVA/PMCh fibers demonstrated more effective and uniform release profiles than the IBU-loaded CA fibers.