Controlled Release of Ibuprofen From Electrospun Biocompatible Nanofibers With In Situ QCM Measurements

Celik G., ÖKSÜZ A.

JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY, cilt.52, ss.76-83, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 52 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1080/10601325.2014.978200
  • Dergi Adı: JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
  • Sayfa Sayıları: ss.76-83

Özet

A series of drug-incorporating electrospun biocompatible nanofibers were fabricated by using the electrospinning process. A hydrophobic drug (ibuprofen, IBU) was directly dissolved with biopolymer systems such as polyvinyl alcohol/plasma modified chitosan (PVA/PMCh), polyvinyl alcohol/chitosan (PVA/Ch) and cellulose acetate (CA) into an organic solvent prior to electrospinning. The release of IBU from drug-loaded electrospun fibers was monitored using a quartz crystal microbalance (QCM). The results were compared with utilizing UV/Vis spectroscopy results. The biocompatible fibers were Fourier transform infrared spectroscopy (FTIR). The IBU-loaded PVA/Ch and PVA/PMCh fibers demonstrated more effective and uniform release profiles than the IBU-loaded CA fibers.