Green ultrasound-assisted synthesis of novel nanoscale schiff base complexes: Structural characterization and multifaceted biological applications supported by theoretical approaches
Journal of the Indian Chemical Society, cilt.103, sa.9, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 103 Sayı: 9
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.jics.2026.102894
- Dergi Adı: Journal of the Indian Chemical Society
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE
- Anahtar Kelimeler: Anti-microbial screening, Coordination behavior, Multifunctional therapeutic potential, Sonication assisted, Systematically evaluated, Tumor progression
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
The rise of antimicrobial resistance, limited efficacy of conventional therapies, and the key role of oxidative stress in disease progression necessitate advanced multifunctional bioinorganic systems. A bidentate Schiff base ligand (CHMS) was synthesized via sonication-assisted condensation of salicylamide and 4-chlorobenzaldehyde, followed by coordination with Mo(VI), Bi(III), Cu(II), and Ag(I). Structural features were confirmed using FT-IR, UV–Vis, 1H/13C NMR, mass spectrometry, CHN-metal analysis, magnetic measurements, and TGA, supported by DFT calculations. Powder X-ray diffraction (PXRD) analysis confirmed the crystalline nature and phase purity of the synthesized complexes, revealing distinct diffraction patterns consistent with monoclinic lattices and distorted octahedral coordination environments around the metal centers except CHMSAg complex. TEM analysis revealed nanosized particles (25–64 nm) with semi-circular morphology. Biological evaluation showed enhanced activity upon metal coordination. In DPPH assays, CHMSCu (IC50 = 16.50 μg mL−1), CHMSAg (18.25 μg mL−1), and CHMSBi (22.10 μg mL−1) exhibited significantly higher antioxidant activity than the free ligand (50.75 μg mL−1) and ascorbic acid (55.60 μg mL−1). Antimicrobial studies demonstrated broad-spectrum activity for CHMSCu and CHMSAg against Gram-positive and Gram-negative bacteria, while CHMSBi showed strong bacteriostatic effects. Cytotoxicity assays against HCT116, MCF-7, and HepG2 cell lines indicated that CHMSCu and CHMSMo possess the lowest IC50 values, reflecting superior anticancer activity. Molecular docking confirmed favorable binding interactions with targets associated with oxidative stress, microbial viability, and cancer progression, highlighting these complexes as promising multifunctional therapeutic candidates.