The K-40, Ra-226 and Th-232 concentration is due to the magmatic structure of the earth and it can be varied from place to place. Osmaniye is located in the Eastern side of Mediteranean Region. It holds the climatic characteristics of the same region and arises with Middle Taurus Mountains from west to North and with Amonos Mounations in East and West-east parts and is situated between 35 degrees.52'-36 degrees.42' east longitudes and 36 degrees.57'-37 degrees.45' north latitudes. In this study, the natural radioactivity concentrations K-40, Ra-226 and Th-232 in some soil samples collected in Osmaniye have been investigated. The measurements have been performed using 3x3 '' NaI(Tl) detector system.