Plasma 8-isoPGF2 alpha and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease


Sirin F. B., Doguc D. K., VURAL H., EREN İ., Inanli I., SÜTÇÜ R., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.5, pp.1073-1077, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1406-134
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1073-1077
  • Keywords: Alzheimer disease, minimal cognitive impairment, oxidative stress, isoprostane, melatonin, LIPID-PEROXIDATION, CEREBROSPINAL-FLUID, OXIDATIVE STRESS, PINEAL, BRAIN, URINE
  • Süleyman Demirel University Affiliated: Yes

Abstract

Background/aim: F2 alpha-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not.