R202Q/M694V as novel MEFV gene mutations in chronic periodontitis and familial Mediterranean fever


FENTOĞLU Ö. , DİNÇ G. , BAĞCI Ö., DOĞRU A. , İLHAN İ. , KIRZIOĞLU F. Y. , ...More

JOURNAL OF PERIODONTAL RESEARCH, vol.52, no.6, pp.994-1003, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1111/jre.12467
  • Title of Journal : JOURNAL OF PERIODONTAL RESEARCH
  • Page Numbers: pp.994-1003

Abstract

Background and Objective: Familial Mediterranean fever (FMF) and chronic periodontitis are inflammatory diseases leading to an increase in the number of inflammasomes. To date, no published studies have reported on mutations in the Mediterranean fever (MEFV) gene in patients with chronic periodontitis, although the roles of MEFV gene mutations in FMF and FMF-associated amyloidosis (FMF-A) are well known. Therefore, the aim of this study was to evaluate the frequencies of MEFV gene mutations and serum amyloid A (SAA) and high-sensitivity C-reactive protein (hs-CRP) levels in patients with chronic periodontitis, FMF and FMF-A.