R202Q/M694V as novel MEFV gene mutations in chronic periodontitis and familial Mediterranean fever


FENTOĞLU Ö. , DİNÇ G. , BAĞCI Ö., DOĞRU A. , İLHAN İ. , KIRZIOĞLU F. Y. , ...Daha Fazla

JOURNAL OF PERIODONTAL RESEARCH, cilt.52, ss.994-1003, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 52 Konu: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1111/jre.12467
  • Dergi Adı: JOURNAL OF PERIODONTAL RESEARCH
  • Sayfa Sayıları: ss.994-1003

Özet

Background and Objective: Familial Mediterranean fever (FMF) and chronic periodontitis are inflammatory diseases leading to an increase in the number of inflammasomes. To date, no published studies have reported on mutations in the Mediterranean fever (MEFV) gene in patients with chronic periodontitis, although the roles of MEFV gene mutations in FMF and FMF-associated amyloidosis (FMF-A) are well known. Therefore, the aim of this study was to evaluate the frequencies of MEFV gene mutations and serum amyloid A (SAA) and high-sensitivity C-reactive protein (hs-CRP) levels in patients with chronic periodontitis, FMF and FMF-A.