R202Q/M694V as novel MEFV gene mutations in chronic periodontitis and familial Mediterranean fever
JOURNAL OF PERIODONTAL RESEARCH, vol.52, no.6, pp.994-1003, 2017 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 52 Issue: 6
- Publication Date: 2017
- Doi Number: 10.1111/jre.12467
- Journal Name: JOURNAL OF PERIODONTAL RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.994-1003
- Keywords: amyloidosis, C-reactive protein, familial Mediterranean fever, MEFV gene mutations, periodontitis, serum amyloid A, C-REACTIVE PROTEIN, RENAL AMYLOIDOSIS, TURKISH PATIENTS, R202Q ALTERATION, AA AMYLOIDOSIS, GENOTYPE, DISEASE, SERUM, PHENOTYPE, TURKEY
- Süleyman Demirel University Affiliated: Yes
Abstract
Background and Objective: Familial Mediterranean fever (FMF) and chronic periodontitis are inflammatory diseases leading to an increase in the number of inflammasomes. To date, no published studies have reported on mutations in the Mediterranean fever (MEFV) gene in patients with chronic periodontitis, although the roles of MEFV gene mutations in FMF and FMF-associated amyloidosis (FMF-A) are well known. Therefore, the aim of this study was to evaluate the frequencies of MEFV gene mutations and serum amyloid A (SAA) and high-sensitivity C-reactive protein (hs-CRP) levels in patients with chronic periodontitis, FMF and FMF-A.