Determination of Optimum Separation Condition for Some Carbapenem Antibiotics Using RPLC with the Aid of Central Composite Design and Desirability Function

Gundogan, Busra; ÇUBUK DEMİRALAY, Ebru; Daldal, Yasar; ÜSTÜN, Zehra

doi:10.2174/1573412912666160822114927

Determination of Optimum Separation Condition for Some Carbapenem Antibiotics Using RPLC with the Aid of Central Composite Design and Desirability Function

Gundogan B., ÇUBUK DEMİRALAY E., Daldal Y. D., ÜSTÜN Z.

CURRENT PHARMACEUTICAL ANALYSIS, vol.13, no.2, pp.100-109, 2017 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 13 Issue: 2
Publication Date: 2017
Doi Number: 10.2174/1573412912666160822114927
Journal Name: CURRENT PHARMACEUTICAL ANALYSIS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.100-109
Süleyman Demirel University Affiliated: Yes

Abstract

Background: In order to acquire the best chromatographic condition with maximum resolution and minimum analysis time, the central composite design (CCD) added with Derringer's desirability function was utilised in order to separation of doripenem, meropenem and ertapenem.