Determination of Optimum Separation Condition for Some Carbapenem Antibiotics Using RPLC with the Aid of Central Composite Design and Desirability Function


Gundogan B., ÇUBUK DEMİRALAY E. , Daldal Y. D. , ÜSTÜN Z.

CURRENT PHARMACEUTICAL ANALYSIS, vol.13, no.2, pp.100-109, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.2174/1573412912666160822114927
  • Title of Journal : CURRENT PHARMACEUTICAL ANALYSIS
  • Page Numbers: pp.100-109

Abstract

Background: In order to acquire the best chromatographic condition with maximum resolution and minimum analysis time, the central composite design (CCD) added with Derringer's desirability function was utilised in order to separation of doripenem, meropenem and ertapenem.