Determination of Optimum Separation Condition for Some Carbapenem Antibiotics Using RPLC with the Aid of Central Composite Design and Desirability Function


Gundogan B., ÇUBUK DEMİRALAY E. , Daldal Y. D. , ÜSTÜN Z.

CURRENT PHARMACEUTICAL ANALYSIS, cilt.13, ss.100-109, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 13 Konu: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1573412912666160822114927
  • Dergi Adı: CURRENT PHARMACEUTICAL ANALYSIS
  • Sayfa Sayıları: ss.100-109

Özet

Background: In order to acquire the best chromatographic condition with maximum resolution and minimum analysis time, the central composite design (CCD) added with Derringer's desirability function was utilised in order to separation of doripenem, meropenem and ertapenem.