Determination of Optimum Separation Condition for Some Carbapenem Antibiotics Using RPLC with the Aid of Central Composite Design and Desirability Function

Gundogan, Busra; ÇUBUK DEMİRALAY, Ebru; Daldal, Yasar; ÜSTÜN, Zehra

doi:10.2174/1573412912666160822114927

Determination of Optimum Separation Condition for Some Carbapenem Antibiotics Using RPLC with the Aid of Central Composite Design and Desirability Function

Gundogan B., ÇUBUK DEMİRALAY E. , Daldal Y. D. , ÜSTÜN Z.

CURRENT PHARMACEUTICAL ANALYSIS, vol.13, no.2, pp.100-109, 2017 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 13 Issue: 2
Publication Date: 2017
Doi Number: 10.2174/1573412912666160822114927
Title of Journal : CURRENT PHARMACEUTICAL ANALYSIS
Page Numbers: pp.100-109

Abstract

Background: In order to acquire the best chromatographic condition with maximum resolution and minimum analysis time, the central composite design (CCD) added with Derringer's desirability function was utilised in order to separation of doripenem, meropenem and ertapenem.