Determination of Optimum Separation Condition for Some Carbapenem Antibiotics Using RPLC with the Aid of Central Composite Design and Desirability Function

Gundogan, Busra; ÇUBUK DEMİRALAY, Ebru; Daldal, Yasar; ÜSTÜN, Zehra

doi:10.2174/1573412912666160822114927

Determination of Optimum Separation Condition for Some Carbapenem Antibiotics Using RPLC with the Aid of Central Composite Design and Desirability Function

Gundogan B., ÇUBUK DEMİRALAY E., Daldal Y. D., ÜSTÜN Z.

CURRENT PHARMACEUTICAL ANALYSIS, cilt.13, sa.2, ss.100-109, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 13 Sayı: 2
Basım Tarihi: 2017
Doi Numarası: 10.2174/1573412912666160822114927
Dergi Adı: CURRENT PHARMACEUTICAL ANALYSIS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.100-109
Süleyman Demirel Üniversitesi Adresli: Evet

Özet

Background: In order to acquire the best chromatographic condition with maximum resolution and minimum analysis time, the central composite design (CCD) added with Derringer's desirability function was utilised in order to separation of doripenem, meropenem and ertapenem.