© 2014, Springer Science+Business Media New York.Nuclear reaction codes give us simplicity to investigate phenomena of nuclear physics. There have many computer programs such as TALYS, EMPIRE, ALICE/ASH, PCROSS, FLUKA and GEANT4. The stopping power of alpha, deuteron, proton and triton in 54Fe materials is acquired as it has helpful applications of shielding and choosing the proper thickness of the target. Level density is very important to understanding nuclear reaction mechanism. The knowledge of level density for reaction cross-section calculations are required for various application such as astrophysics, accelerator driven sub-critical systems, nuclear medicine, fission and fusion reactor design and neutron capture. In this study, we calculated the cross-sections of 54Fe using TALYS 1.6 and EMPIRE 3.1 codes for different reactions through the four level density models. Stopping powers and penetrating distances were calculated for the alpha, deuteron, proton and triton particles, taking into consideration all possible reactions in 54Fe for incident energies of 1–45 MeV using GEANT4 calculation code. The obtained reaction cross-section results have been compared with the each other and against the experimental nuclear reaction data existing in EXFOR database.