Fetal pulmonary injury following single high-dose intra-amniotic betamethasone treatment in preterm goat kids


Antlyali M., Ozmen O., Haligur M., SEZİK M.

JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION, cilt.13, sa.4, ss.242-246, 2012 (ESCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5152/jtgga.2012.38
  • Dergi Adı: JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION
  • Sayfa Sayıları: ss.242-246

Özet

Objective: Fetal lung maturation is an extremely important process that is necessary for the survival of the neonates. Conventionally, corticosteroids are administered maternally for inducing fetal lung maturation in preterm fetuses. Alternatively, single-dose intra-amniotic (IA) treatment might be speculated to improve lung maturity. In the goat model, we recently showed that high-dose IA betamethasone (BM) was associated with an increased number of stillbirths and emphysematous changes. The aim of the present study is to expand our previous findings and evaluate the histopathological effects of IA injection of a single high-dose of BM 48 h before induced preterm delivery, using our previously collected specimens.